What is THC?
Delta-9-tetrahydrocannabinol (THC) is the most famous and abundant psychoactive compound in cannabis. When consumed, THC binds to CB1 receptors in the brain—the same receptors activated by anandamide, our body's natural 'bliss molecule.' This binding triggers a cascade of effects: dopamine release, altered perception, euphoria, and the characteristic 'high.' THC's discovery in 1964 by Raphael Mechoulam revolutionized our understanding of cannabis and led to the discovery of the entire endocannabinoid system.
How It Works
THC mimics anandamide, a naturally occurring endocannabinoid in your body. It binds primarily to CB1 receptors concentrated in the brain and central nervous system, causing the release of dopamine and creating feelings of euphoria. It also binds to CB2 receptors in the immune system, contributing to anti-inflammatory effects.
Medical Uses
Pain Relief
Effective for chronic pain, neuropathic pain, and inflammation
Nausea/Vomiting
FDA-approved (as Marinol) for chemotherapy-induced nausea
Appetite Stimulation
Helps with wasting syndrome, eating disorders, and cancer cachexia
Muscle Spasms
Reduces spasticity in multiple sclerosis and other conditions
Sleep
Helps with insomnia, especially when combined with CBN
PTSD
May help reduce nightmares and anxiety in PTSD patients
Dosing Guide
Microdose
1-2.5mgSub-perceptual, focus and mood enhancement
Low
2.5-5mgMild effects, good for beginners
Moderate
5-15mgFull psychoactive effects, recreational
High
15-30mgStrong effects, experienced users
Very High
30mg+Intense effects, high tolerance only
Synergies (Entourage Effect)
CBD moderates THC's psychoactive effects and reduces anxiety
Enhances sedative effects and increases absorption
Elevates mood and may reduce anxiety
Amplifies sedative effects for sleep
Research Highlights
- FDA approved synthetic THC (Marinol/Dronabinol) for nausea and appetite stimulation
- Studies show effectiveness for chronic pain reduction
- Research suggests neuroprotective properties in certain conditions
- Ongoing trials for PTSD, anxiety, and neurodegenerative diseases
Effects
Potential Side Effects
- •Anxiety or paranoia (dose-dependent)
- •Dry mouth (cottonmouth)
- •Red eyes
- •Increased heart rate
- •Impaired short-term memory
- •Impaired motor coordination
- •Drowsiness (especially indica strains)
Common In
Best Products For THC
- Flower
- Vapes
- Edibles (for long-lasting effects)
- RSO (for medical use)
Receptor Binding
Legal Status
Schedule I federally (USA); Legal in many states; Varies internationally
Related Cannabinoids
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Consult with a healthcare provider before using cannabis products, especially if you have existing health conditions or take medications.