What is THCv?
THCv is THC's energetic cousin, with a shorter carbon chain that changes its effects dramatically. At low doses, THCv acts as a CB1 antagonist—it blocks the receptor rather than activating it. This is why it's associated with appetite suppression and clear-headed energy. At higher doses, THCv becomes a CB1 agonist like THC, producing psychoactive effects, but the high is described as shorter, clearer, and more stimulating. THCv is naturally found in African sativa landraces like Durban Poison but is rare in most commercial strains.
How It Works
THCv's effects depend on dose. At low doses, it's a CB1 antagonist—it blocks the receptor, explaining appetite suppression and lack of intoxication. At higher doses, it becomes a CB1 agonist like THC. It also interacts with CB2 receptors and may affect 5-HT1A serotonin receptors.
Medical Uses
Weight Management
Appetite suppression; no munchies
Diabetes
May improve glucose tolerance and insulin sensitivity
PTSD
Reduces panic attacks without sedation
Bone Growth
Stimulates bone cell growth
Anxiety
Reduces anxiety without heavy sedation
Dosing Guide
Sub-threshold
1-5mgAppetite suppression, no high
Low
5-10mgEnergy and focus, mild effects
Moderate
10-20mgClear, energetic high
High
20mg+Strong but short psychoactive effects
Synergies (Entourage Effect)
Modulates and shortens THC's effects
Enhanced anxiety relief with clarity
Amplified mood and energy effects
Enhanced focus and mental clarity
Research Highlights
- Reduced blood sugar and improved insulin resistance in diabetic mice
- Showed anti-obesity effects in animal models
- Reduced tremors and brain lesions in Parkinson's models
- FDA has not approved any THCv products yet
Effects
Potential Side Effects
- •Appetite suppression (may be desired)
- •Short-duration high at high doses
- •Increased energy may interfere with sleep
- •Less paranoia than THC for most people
Common In
Best Products For THCv
- Durban Poison flower
- African landrace strains
- THCv isolates
- Daytime formulations
Receptor Binding
Legal Status
Varies; often in legal gray area
Related Cannabinoids
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Consult with a healthcare provider before using cannabis products, especially if you have existing health conditions or take medications.