What is CBD?
Cannabidiol (CBD) has transformed from an obscure compound to a wellness phenomenon. Unlike THC, CBD doesn't produce a high—it actually modulates the effects of THC and can reduce anxiety caused by too much THC. CBD works through multiple pathways: it interacts with serotonin receptors (explaining anti-anxiety effects), TRPV1 receptors (pain modulation), and indirectly influences the endocannabinoid system by inhibiting the breakdown of anandamide. The 2018 Farm Bill legalized hemp-derived CBD federally, leading to an explosion of CBD products.
How It Works
CBD works through multiple mechanisms rather than directly binding to CB1/CB2 receptors. It inhibits FAAH (the enzyme that breaks down anandamide), modulates serotonin 5-HT1A receptors, activates TRPV1 vanilloid receptors, and acts as a negative allosteric modulator of CB1—meaning it changes how THC binds to these receptors.
Medical Uses
Epilepsy
FDA-approved (Epidiolex) for Dravet and Lennox-Gastaut syndromes
Anxiety
Multiple studies show anxiolytic effects
Inflammation
Potent anti-inflammatory through multiple pathways
Pain
Effective especially for inflammatory and neuropathic pain
Sleep
Helps with sleep disorders, especially anxiety-related insomnia
Addiction
Promising research for reducing cravings and withdrawal
Dosing Guide
Microdose
5-10mgSubtle wellness support
Low
10-25mgMild relaxation, daily wellness
Moderate
25-50mgNoticeable effects, anxiety relief
High
50-100mgStrong therapeutic effects
Very High
100mg+Medical use (e.g., epilepsy)
Synergies (Entourage Effect)
Balances and extends THC effects, reduces anxiety
Enhanced anti-inflammatory and neuroprotective effects
Amplified calming and anti-anxiety effects
Enhanced pain relief through CB2 activation
Research Highlights
- First cannabis-derived drug (Epidiolex) approved by FDA for epilepsy
- Demonstrated anxiolytic effects in multiple human trials
- Shows promise for addiction treatment (opioids, nicotine)
- Anti-inflammatory effects verified through multiple mechanisms
Effects
Potential Side Effects
- •Generally very well-tolerated
- •Dry mouth
- •Drowsiness at high doses
- •Potential drug interactions (cytochrome P450)
- •Diarrhea (rare, at very high doses)
- •Changes in appetite
Common In
Best Products For CBD
- Tinctures (precise dosing)
- Topicals (localized relief)
- Capsules (consistent dosing)
- Full-spectrum products (entourage effect)
Receptor Binding
Legal Status
Legal from hemp (<0.3% THC) in USA; Epidiolex FDA-approved; Varies internationally
Related Cannabinoids
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Consult with a healthcare provider before using cannabis products, especially if you have existing health conditions or take medications.