What is CBG?
Cannabigerol (CBG) is often called the 'mother' or 'stem cell' cannabinoid because it's the chemical precursor to THC, CBD, and CBC. In young cannabis plants, CBGa (the acidic form) is abundant, but as the plant matures, enzymes convert most of it into other cannabinoids—leaving only about 1% CBG in mature plants. This scarcity made CBG expensive and rare, but new CBG-rich cultivars are changing that. Non-psychoactive like CBD, CBG has its own unique therapeutic profile and is gaining attention for its potential in treating conditions that don't respond well to THC or CBD alone.
How It Works
CBG interacts with both CB1 and CB2 receptors but with lower affinity than THC. It may act as a partial agonist at these receptors. CBG also affects alpha-2 adrenergic receptors, 5-HT1A serotonin receptors, and blocks TRPM8 channels—explaining its diverse effects.
Medical Uses
Glaucoma
Reduces intraocular pressure effectively
IBD
Promising research for inflammatory bowel disease
Bacterial Infections
Antibacterial properties, including against MRSA
Neuroprotection
Potential for Huntington's disease and other conditions
Bladder Dysfunction
May help with overactive bladder
Appetite
Stimulates appetite without psychoactive effects
Dosing Guide
Low
5-15mgSubtle effects, daily wellness
Moderate
15-30mgNoticeable focus and calm
High
30-50mgStrong therapeutic effects
Synergies (Entourage Effect)
Enhanced anti-inflammatory and neuroprotective effects
May buffer psychoactive effects while adding focus
Combined anti-inflammatory action
Enhanced focus and mental clarity
Research Highlights
- Demonstrated antibacterial activity against antibiotic-resistant bacteria
- Reduced inflammation in mouse models of IBD
- Showed neuroprotective effects in Huntington's disease models
- Research ongoing for cancer cell inhibition
Effects
Potential Side Effects
- •Very limited data on side effects
- •Generally well-tolerated
- •May cause dry mouth
- •Possible drowsiness at high doses
Common In
Best Products For CBG
- CBG-rich flower
- CBG:CBD ratio tinctures
- Daytime formulations
Receptor Binding
Legal Status
Legal in most jurisdictions (non-psychoactive)
Related Cannabinoids
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Consult with a healthcare provider before using cannabis products, especially if you have existing health conditions or take medications.