What is CBC?
Cannabichromene (CBC) is the third most abundant cannabinoid in cannabis, yet it remains relatively unknown. Unlike THC and CBD, CBC doesn't bind strongly to CB1 or CB2 receptors. Instead, it works through other pathways: activating TRPV1 and TRPA1 channels (involved in pain perception) and inhibiting the reuptake of anandamide. This makes CBC a powerful 'entourage' player—it enhances the effects of other cannabinoids rather than producing strong effects on its own. Research suggests CBC may be particularly valuable for mood, pain, and inflammation.
How It Works
CBC doesn't bind well to CB1 or CB2, but it activates TRPV1 and TRPA1 ion channels (pain and inflammation), inhibits the breakdown of anandamide (our body's THC), and interacts with other non-cannabinoid receptors. This multi-target approach makes it valuable in full-spectrum products.
Medical Uses
Depression
Antidepressant effects observed in animal studies
Pain
Analgesic effects through TRPV1/TRPA1 activation
Inflammation
Potent anti-inflammatory action
Acne
Reduces sebum production and inflammation
Brain Health
May promote neural stem cell growth (neurogenesis)
Dosing Guide
As Part of Full-Spectrum
N/AUsually consumed via full-spectrum products
Isolated
10-50mgWhen using CBC isolate
Synergies (Entourage Effect)
Enhanced pain relief and anti-inflammatory effects
Amplified mood and anti-anxiety benefits
Combined anti-inflammatory action
Multi-pathway pain and inflammation relief
Research Highlights
- Showed antidepressant effects in mouse models
- Demonstrated neurogenesis (brain cell growth) promotion
- Exhibited potent anti-inflammatory effects in rat models
- Reduced acne and sebum production in human cell studies
Effects
Potential Side Effects
- •Very limited side effect data
- •Generally well-tolerated
- •No known serious adverse effects
Common In
Best Products For CBC
- Full-spectrum extracts
- Whole-plant products
- CBC isolates (rare)
Receptor Binding
Legal Status
Legal in most jurisdictions (non-psychoactive)
Related Cannabinoids
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Consult with a healthcare provider before using cannabis products, especially if you have existing health conditions or take medications.